TiO₂ inverse opal could offer a promising solution in search to enhance the light harvesting efficiency of dye-sensitized solar cell (DSSC) due to its large interconnected pores for better penetration of dye and photon localization in the red edge of photonic band gap for significant enhancement of dye absorption. In view of sensitizers, semiconductor quantum dots (QDs) have attracted much attention as dye substitute due to its tunable optical properties to maximize the solar absorption and capability of carrier multiplication through impact ionization. Furthermore, its instability generally irritating the efficiency could be covered by coating with more stable materials. In this study, we propose the use of TiO₂ inverse opal solar cells sensitized with CdSe QDs by chemical deposition and introduce a suggestion for better solar cells, namely surface modification with ZnS and insertion of fluoride (F¯) ions on the TiO2/CdSe and CdSe/ZnS interfaces. The photovoltaic properties increased by surface modification and larger latex template size. The former indicates the passivation of surface states on TiO2 (by F¯ ions) and CdSe QDs (by F¯ ions and ZnS). The latter shows that the resulted larger pores in the TiO₂ inverse opal favoring the easy penetration of Cd and Se precursors during deposition, as well as the electrolyte. Further investigations are still continuing to determine the exact effect of each modification and the potential of other latex size. The energy conversion efficiency to 3.4% could be achieved; where best to our knowledge this value is the highest for QD sensitized solar cells.